Thymic Stromal Lymphopoietin: To Cut a Long Story Short

Thymic Stromal Lymphopoietin: To Cut a Long Story Short

Thymic stromal lymphopoietin (TSLP) was identified more than 20 years ago as a secreted factor of a mouse thymic stromal cell line; later, a human orthologue was also identified. The signaling pathway triggered by TSLP has been extensively studied, and upregulation of the cytokine itself is linked to the pathogenesis of numerous Th2-related diseases, including atopic dermatitis, asthma, allergi...

Thymic Stromal Lymphopoietin-Dependent

Thymic Stromal Lymphopoietin Interferes

Thymic Stromal Lymphopoietin Amplifies

Thymic stromal lymphopoietin and cancer.

Originally shown to promote the growth and activation of B cells, thymic stromal lymphopoietin (TSLP) is now known to have wide-ranging effects on both hematopoietic and nonhematopoietic cell lineages. These include dendritic cells, basophils, mast cells, B cells, epithelial cells, and CD4(+), CD8(+), and NK T cells. Although TSLP's role in the promotion of Th2 responses has been studied extens...